This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1896 Excerpt: ... implied in the term "interstitial nephritis," there may be found in well prepared specimens, other appearances which are not explained by the doctrine in question and which seem to be inconsistent with it. I will now endeavour to describe and illustrate the chief of these appearances. The convoluted tubes of the cortex are the chief seat of structural changes. In some sections of the cortex of the kidney there may be found tubes presenting a normal appearance, but these are rare. Many tubes present the appearance represented in Fig. i2. The epithelial lining has become disintegrated and for the most part removed, appearing in the urine in the form of granular casts. The transverse sections Fig. i2.--Transverse Sections Of Tubes, Containing Only Granular Debris Of Epithelium. At one end of the section the contents of the tubes have been washed away, and the sections of the basement-membrane form three empty rings.--x 200. of tubes in this condition have somewhat the appearance of isolated globular cysts, and they have been so described by more than one observer. Fig. i3.--Tubes Hore Or Less Completely Denudld Of Epithelium. Some transversely divided and cyst-like; others seen lengthwise. x 200. When, in the same section, some tubes appear transversely divided while others present themselves lengthwise, as in Fig. i3, but all having the same structure and contents, it is easily seen that the cystlike appearance is given by transverse sections of partially or completely denuded tubes. Some of the denuded tubes are seen to be filled with a so-called hyaline or colloid material. This material often appears in the urine in the form of "large hyaline casts." Some scattered nuclei appear in the structureless intertubular spaces. (Fig. i4).--The...