This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1921 Excerpt: ...rapid in mice which arc young, well nourished, and vigorous; (b) less rapid in mice older or less vigorous or less nourished; (c) very slow in mice which are old, feeble, under-nourished, or afflicted with a destructive complicating disease." Miss Slye's conclusions are ample proof that cancer is a regenerativedestructive process. CELL DIFFERENTIATION AND ACTIVITY In a recent paper on squamous-cell epithelioma of the lip,2 I brought out the fact that the more an epithelioma tends to differentiate, the lower is the degree of malignancy. I believe this principle can be applied to malignant neoplasia in general. Very few melanotic or nonmelanotic melano-epitheliomas show any tendency to differentiate, hence the high degree of malignancy; however, gland formations and squamous-cells are sometimes found in these neoplasms. The question has often been asked why the basal-cell epithelioma is of such a low degree of malignancy when it is made up of undifferentiated cells. It has been suggested that basal-cell epithelioma passes through a short cycle and differentiates into basal cells, while squamous-cell epitheliomas pass through a longer cycle in order to differentiate into squamous-cells.5 It is well known that the most of the cells of a basal-eell epithelioma bear a close resemblance to the normal basal or regenerative cells of the epidermis; however, sometimes there are cells in this type'of neoplasm which contain round nuclei with deeply staining single nucleoli, "one-eyed cells;" sometimes the nuclei are irregular in outline and contain more than one nucleolus or none. I can see no differentiation in these cells; they bear a striking resemblance to the Grade 4 squamous-cell epithelioma or the melanotic epithelioma. Whenever these cells predomi...
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