Schizophrenia occurs in around 1 in every 100 people, affecting both men and women equally and with a typical onset of between 15 and 35 years of age. It is characterised by impairments in reality, most commonly hallucinations and delusions. As it is a highly complex condition it is often confused with other mental disorders such as bipolar disorder. While there are many effective pharmacological treatments for the condition, clinicians need to be aware of existing pitfalls, including problems with treatment adherence and metabolic affects of anti-psychotic therapies. Written by two global opinion leaders on management of psychosis, this user-friendly practical guide outlines the diagnosis, evaluation and treatment of patients with schizophrenia.