For more than 50 years, scientists, clinicians and students have used "Goodman and Gilman" for reference on the pharmacokinetics, mechanisms of action and therapeutic application of drugs. This edition contains the latest information on molecular pharmacology as it redefines the definitive database of pharmacologic therapeutics. All the newly approved drugs are included. Also, for each drug class, there is a complete overview of chemical composition, mechanisms of action, indications and contraindications, clinical applications and potential side-effects. As a course text or a daily reference in clinical practice, the text offers a useful mix of basic science and clinical coverage as it pertains to effective drug therapy.