Book Description: The past decade has witnessed the remarkable development of new, highly effective approaches for the treatment of advanced prostate cancer - new hormonal agents, cytotoxic chemotherapeutic drugs, targeted therapeutics and immunotherapy. This book thoroughly reviews the current state of systemic therapy for prostate cancer, including agents approved or undergoing investigation, building on the intensive research of the past three decades that has elucidated the specific molecular mechanisms by which the prostate cancer cell achieves castration resistance. This timely collection of chapters from internationally recognized experts covers all the significant advances in the field. The emphasis in each chapter is on the mechanism of action of the agents, and the authors take pains to describe precisely their response rates, impact on survival and adverse effects.